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Author Topic: New Neanderthal promises?  (Read 1537 times)
Jacques Cinq-Mars
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« on: May 16, 2006, 07:50:39 AM »

This is about apparently promising developments in the search for and sequencing of Neanderthal nuclear DNA:

Quote
Neanderthal DNA yields to genome foray.
Genetic material sequenced from 45,000-year-old male.
NATURE -- Published online: 16 May 2006

Rex Dalton


The first nuclear DNA sequences from a Neanderthal (Homo neanderthalensis) have been reported. The results should provide clues about when certain diseases, or traits such as hair or skin colour, arose. They also have geneticists excited about the idea of sequencing a Neanderthal genome.

Svante Pääbo, a palaeogeneticist at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, began his Neanderthal Genome Project about two years ago. He and his team have probed 60 Neanderthal specimens from museums for hints that the DNA might have survived millennia of degradation. The species lived across Europe and western Asia from 300,000 to around 30,000 years ago, with the first specimen found in 1856 near Dusseldorf, Germany.

Two of the specimens showed promise, and on 12 May Pääbo's team reported at the Biology of Genomes meeting at New York's Cold Spring Harbor Laboratory that they had managed to sequence around a million base pairs of nuclear DNA — around 0.03% of the genome — from one of them. This is a 45,000-year-old male specimen found in Vindija Cave outside Zagreb, Croatia.

Click HERE for access to the full news article.

Jacques Cinq-Mars

PS I did check the Nature site, but as of a few minutes ago, the actual article was nowhere to be found. With luck, the listing will be updated later today.


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lagarvelho
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« Reply #1 on: May 16, 2006, 06:00:31 PM »

Jacques:

Couldn't access the article(sniff!)   I'm not a subscriber.  Oh well. . . .
Anne G
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Jacques Cinq-Mars
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« Reply #2 on: May 16, 2006, 07:35:26 PM »

Jacques:

Couldn't access the article(sniff!)   I'm not a subscriber.  Oh well. . . .
Anne G

This is curious. The link I posted this morning was unrestricted and perfectly functional. I just checked and noted that the news article has actually disappeared. I'll see what I can do.

Jacques
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Daryl Habel
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« Reply #3 on: May 16, 2006, 11:26:43 PM »

This is curious. The link I posted this morning was unrestricted and perfectly functional. I just checked and noted that the news article has actually disappeared. I'll see what I can do.

Jacques

Not so curious.  Nature news articles have a tendency to be unrestricted for a day or so, then revert to subscription only.  They were quick with this one.  In any case, John Hawks has a pretty good review on his weblog at CLICK HERE.

At present, this appears to be only a preliminary announcement of  the first successful recovery of Neanderthal nuclear DNA , without a refereed publication and lacking details.

Dar
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Daryl Habel
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Jacques Cinq-Mars
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« Reply #4 on: May 17, 2006, 07:45:01 AM »

This is curious. The link I posted this morning was unrestricted and perfectly functional. I just checked and noted that the news article has actually disappeared. I'll see what I can do.

Jacques

Not so curious.  Nature news articles have a tendency to be unrestricted for a day or so, then revert to subscription only.  They were quick with this one.  In any case, John Hawks has a pretty good review on his weblog at CLICK HERE.

At present, this appears to be only a preliminary announcement of  the first successful recovery of Neanderthal nuclear DNA , without a refereed publication and lacking details.

Dar
You are right, although I find such marketing(?) practice on the part of Nature slightly annoying. At any rate, I am fortunate enough to  have access to Dalton's piece and -- John Hawks'review notwithstanding -- it certainly does not add much to my understanding of who's who in the molecular world.

Jacques
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lagarvelho
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« Reply #5 on: May 17, 2006, 07:57:18 PM »

Jacques, Dar, and all:

Just to letcha all know, I still can't get access to the Nature article.  And for Jaccques, if it's any comfort to you, I'm just as annoyed about this as you are.  But that's another story.  in any case, I *did* read the Hawks blog on this subject, and while I'm not any more familiar with who's who in the molecular genetic world than Jacques, I tend nevertheless to side with Hawks in his conclusions.
Anne G
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