I visited Big Bone Lick this Monday. At the interstate visitor center I watched the desk clerk tell a visitor that there were no Indians in Kentucky, but that it had only been a hunting ground.
The nature center at Big Bone Lick was closed, but the gift shop was open. Apparently the folks in Kentucky never thought to combine the two.
Following Kentucky's sterling academic tradition, Nebraska had been the last to excavate the site. The dates:http://inside.msj.edu/academics/faculty/davisr/bigbone/fauna.htm
In other words bison long before 1630 CE.
The site itself was in poor shape, and could be better run. Some of the native american materials were close to insulting. Apparently no one has thought to look for a nearby fresh water spring for habitation sites.
Lest I leave you with a bad impression of all Kentuckians, I also spoke with a Long Hunter from Mt Carmel during the weekend, and I learned that a buffulo trail also ran along 133 (?) north south from Blue Lick, and that parts of the trace survive. My guess is that folsom followed it as well.